SCHEMBL6852028

SCHEMBL6852028

OCC=Cc1ccc(-c2ncccn2)s1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.41
KDM4E B2RXH2 2/20 0.36
NPC1 O15118 1/20 0.36
GLA P06280 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
CYP2E1 P05181 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2A6 P11509 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2B6 P20813 1/20 0.32
CYP2C19 P33261 1/20 0.32
SLC5A2 P31639 1/20 0.31
ALDH1A1 P00352 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
HDAC3 O15379 1/20 0.30
HDAC4 P56524 1/20 0.30
HDAC7 Q8WUI4 1/20 0.30
HDAC2 Q92769 1/20 0.30
HDAC10 Q969S8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6852022 1.00 HDAC1 (0.41) HDAC1KDM4ENPC1GLAMAPT
SCHEMBL6850817 0.85 KDM4E (0.56) HDAC1KDM4ENPC1GLAMAPT
SCHEMBL6850810 0.85 KDM4E (0.56) HDAC1KDM4ENPC1GLAMAPT
SCHEMBL13723564 0.80 HDAC1 (0.39) HDAC1KDM4ENPC1GLAMAPT
SCHEMBL6157887 0.77 HDAC1 (0.41) HDAC1KDM4ENPC1GLAMAPT
SCHEMBL6157883 0.77 HDAC1 (0.41) HDAC1KDM4ENPC1GLAMAPT
SCHEMBL6852067 0.76 CYP2A6 (0.36) KDM4ENPC1GLAMAPTRAB9A
SCHEMBL6852060 0.76 CYP2A6 (0.36) KDM4ENPC1GLAMAPTRAB9A
SCHEMBL6878892 0.75 HDAC1 (0.42) HDAC1KDM4ENPC1GLAMAPT
SCHEMBL6878897 0.75 HDAC1 (0.42) HDAC1KDM4ENPC1GLAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed