SCHEMBL6852604 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	17/20	0.54

▸	PSEN2	P49810	17/20	0.54

▸	APH1B	Q8WW43	17/20	0.54

▸	NCSTN	Q92542	17/20	0.54

▸	APH1A	Q96BI3	17/20	0.54

▸	PSENEN	Q9NZ42	17/20	0.54

▸	KCNH2	Q12809	2/20	0.42

▸	HPGDS	O60760	1/20	0.40

▸	LMNA	P02545	1/20	0.40

▸	THRB	P10828	1/20	0.40

▸	TP53	P04637	1/20	0.39

▸	MAPT	P10636	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6852870	0.87	PSEN1 (0.57)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852713	0.85	PSEN1 (0.56)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852599	0.83	PSEN1 (0.56)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852855	0.83	MAPK1 (0.58)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6854098	0.83	MAPK1 (0.58)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852506	0.82	PSEN1 (0.38)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852850	0.81	PSEN1 (0.58)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852708	0.80	PSEN1 (0.57)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6854498	0.76	PSEN1 (0.52)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852563	0.75	PSEN1 (0.60)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011059048-A1	NOVEL AMIDE DERIVATIVE	大日本住友製薬株式会社 (JP)	2011-05-19	—	—	WO	disclosed