Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.72 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.57 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13458067 | 0.80 | DYRK1A (0.61) | PDGFRBPDGFRATOP1 | |
| SCHEMBL857188 | 0.79 | CDK8 (0.66) | TNIKPDGFRBPDGFRA | |
| SCHEMBL15542823 | 0.79 | MAPK1 (0.70) | MAPK1RIPK1PDGFRBPDGFRA | |
| SCHEMBL12605504 | 0.79 | MAPK1 (1.00) | MAPK1RIPK1PDGFRB | |
| SCHEMBL2275680 | 0.78 | MAPK1 (0.64) | MAPK1RIPK1ALOX5APFEN1 | |
| SCHEMBL18136855 | 0.78 | MAPK1 (0.64) | MAPK1RIPK1ALOX5APFEN1ATR | |
| SCHEMBL28507590 | 0.77 | MAPK1 (0.85) | MAPK1TNIKRIPK1PDGFRBPDGFRA | |
| SCHEMBL27930912 | 0.75 | MAPK1 (0.64) | MAPK1RIPK1PRKDCATR | |
| SCHEMBL19243796 | 0.74 | DYRK1A (0.50) | PDGFRBPDGFRATOP1PRKDCATR | |
| SCHEMBL28348529 | 0.73 | MAPK1 (0.61) | MAPK1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397360-A1 | AZAINDOLES | Aventis Pharma Limited (GB) | 2004-03-17 | — | — | EP | claimed |
| WO-2003000688-A1 | AZAINDOLES | AVENTIS PHARMA LIMITED (GB) | 2003-01-03 | — | — | WO | claimed |