SCHEMBL6853369 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	10/20	0.60

▸	PSEN2	P49810	10/20	0.60

▸	APH1B	Q8WW43	10/20	0.60

▸	NCSTN	Q92542	10/20	0.60

▸	APH1A	Q96BI3	10/20	0.60

▸	PSENEN	Q9NZ42	10/20	0.60

▸	USP30	Q70CQ3	1/20	0.46

▸	HPGD	P15428	1/20	0.45

▸	HTT	P42858	1/20	0.45

▸	NPSR1	Q6W5P4	1/20	0.45

▸	ROCK2	O75116	1/20	0.44

▸	LMNA	P02545	1/20	0.42

▸	THRB	P10828	1/20	0.42

▸	KDM5A	P29375	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6853391	0.92	PSEN1 (0.60)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853388	0.89	PSEN1 (0.56)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853449	0.89	PSEN1 (0.60)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853701	0.87	PSEN1 (0.56)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6854338	0.87	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6852626	0.87	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853432	0.86	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853884	0.85	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853635	0.84	PSEN1 (0.57)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853707	0.83	PSEN1 (0.53)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011059048-A1	NOVEL AMIDE DERIVATIVE	大日本住友製薬株式会社 (JP)	2011-05-19	—	—	WO	disclosed