Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.52 |
| ▸ | HTR2A | P28223 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499075 | 0.83 | HTR2C (0.60) | HTR2CHTR2AKDM4EALOX15MAPK1 | |
| SCHEMBL6496167 | 0.78 | HTR2C (0.48) | HTR2CHTR2AHTR2B | |
| SCHEMBL6483457 | 0.77 | HTR2C (0.64) | HTR2CHTR2AKDM4EALOX15MAPK1 | |
| SCHEMBL6484174 | 0.76 | HTR2C (0.52) | HTR2CHTR2AHTR2B | |
| SCHEMBL6851480 | 0.75 | HTR2C (0.60) | HTR2CHTR2AKDM4EALOX15MAPK1 | |
| SCHEMBL6847473 | 0.75 | HTR2C (0.60) | HTR2CHTR2AKDM4EALOX15MAPK1 | |
| SCHEMBL6847653 | 0.73 | HTR2C (0.65) | HTR2CHTR2AKDM4EALOX15MAPK1 | |
| SCHEMBL6850266 | 0.73 | HTR2C (0.65) | HTR2CHTR2AKDM4EALOX15MAPK1 | |
| Hydrochloric Acid SCHEMBL6495767 | 0.72 | HTR2C (0.64) | HTR2CHTR2AKDM4EALOX15MAPK1 | |
| SCHEMBL6847452 | 0.72 | HTR2C (0.64) | HTR2CHTR2AKDM4EALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173440-B1 | TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS | UPJOHN CO (US) | 2004-09-15 | — | — | EP | claimed |