Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29798888 | 0.89 | MEN1 (0.46) | ESR2MEN1KMT2APTPN1HDAC8 | |
| SCHEMBL2732550 | 0.89 | MEN1 (0.46) | ESR2MEN1KMT2APTPN1HDAC8 | |
| SCHEMBL17573049 | 0.88 | HDAC8 (0.47) | MEN1KMT2APTPN1HDAC8NR1H2 | |
| SCHEMBL19460717 | 0.88 | HDAC8 (0.47) | MEN1KMT2APTPN1HDAC8NR1H2 | |
| SCHEMBL6394031 | 0.86 | NR1H2 (0.59) | MEN1KMT2APTPN1HDAC8NR1H2 | |
| SCHEMBL29676732 | 0.86 | HDAC8 (0.48) | MEN1KMT2APTPN1HDAC8NR1H2 | |
| SCHEMBL18793351 | 0.86 | HDAC8 (0.48) | MEN1KMT2APTPN1HDAC8NR1H2 | |
| SCHEMBL20720097 | 0.86 | HDAC8 (0.48) | MEN1KMT2APTPN1HDAC8NR1H2 | |
| SCHEMBL6394027 | 0.86 | NR1H2 (0.59) | MEN1KMT2APTPN1HDAC8NR1H2 | |
| SCHEMBL19329129 | 0.85 | HDAC8 (0.52) | MEN1KMT2APTPN1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |