SCHEMBL6853985 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	18/20	0.66

▸	PSEN2	P49810	18/20	0.66

▸	APH1B	Q8WW43	18/20	0.66

▸	NCSTN	Q92542	18/20	0.66

▸	APH1A	Q96BI3	18/20	0.66

▸	PSENEN	Q9NZ42	18/20	0.66

▸	KCNH2	Q12809	3/20	0.48

▸	ROCK2	O75116	2/20	0.41

▸	ROCK1	Q13464	2/20	0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL755908	0.81	PSEN1 (0.71)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL759619	0.80	PSEN1 (1.00)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL759041	0.79	PSEN1 (0.84)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL759006	0.76	PSEN1 (0.64)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL761508	0.75	PSEN1 (0.72)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL759555	0.73	PSEN1 (0.71)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL757596	0.72	PSEN1 (0.63)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6853933	0.72	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6854642	0.72	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL759732	0.72	PSEN1 (0.66)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011059048-A1	NOVEL AMIDE DERIVATIVE	大日本住友製薬株式会社 (JP)	2011-05-19	—	—	WO	disclosed