Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.36 |
| ▸ | NQO2 | P16083 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854197 | 1.00 | PLK1 (0.36) | PLK1NQO2SLC6A2MEN1NPC1 | |
| SCHEMBL6856218 | 0.91 | PLK1 (0.40) | PLK1NQO2MEN1MAPTKMT2A | |
| SCHEMBL6856216 | 0.91 | PLK1 (0.40) | PLK1NQO2MEN1MAPTKMT2A | |
| SCHEMBL6855987 | 0.89 | PLK1 (0.36) | PLK1MEN1NPC1MAPTALOX15 | |
| SCHEMBL7004470 | 0.89 | PLK1 (0.36) | PLK1MEN1NPC1MAPTALOX15 | |
| SCHEMBL6850093 | 0.89 | KMT2A (0.36) | PLK1NQO2MEN1NPC1MAPT | |
| SCHEMBL6850090 | 0.89 | KMT2A (0.36) | PLK1NQO2MEN1NPC1MAPT | |
| SCHEMBL6999029 | 0.85 | KMT2A (0.34) | PLK1NQO2MEN1NPC1MAPT | |
| SCHEMBL6999028 | 0.85 | KMT2A (0.34) | PLK1NQO2MEN1NPC1MAPT | |
| SCHEMBL6850316 | 0.81 | PLK1 (0.35) | PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | claimed |
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | disclosed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |