Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.59 |
| ▸ | PRKACA | P17612 | 4/20 | 0.55 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.55 |
| ▸ | AKT2 | P31751 | 1/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.55 |
| ▸ | CHUK | O15111 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857762 | 0.90 | AKT1 (0.62) | AKT1PRKACAAKT3AKT2CDC7 | |
| SCHEMBL6926793 | 0.90 | AKT1 (0.62) | AKT1PRKACAAKT3AKT2CDC7 | |
| SCHEMBL6855147 | 0.86 | CLK2 (0.61) | AKT1PRKACAAKT3AKT2CDC7 | |
| SCHEMBL6854512 | 0.85 | AKT1 (0.73) | AKT1PRKACAAKT3AKT2CDC7 | |
| A-443654 SCHEMBL29374078 | 0.82 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2CDC7 | |
| A-443654 SCHEMBL2738467 | 0.82 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2CDC7 | |
| A-443654 SCHEMBL6855479 | 0.82 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2CDC7 | |
| A-443654 SCHEMBL29644958 | 0.82 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2CDC7 | |
| A-443654 SCHEMBL19859268 | 0.82 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2CDC7 | |
| SCHEMBL6857949 | 0.81 | AKT1 (0.73) | AKT1PRKACAAKT3AKT2DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831175-B2 | Such as N,N-dimethyl-N-(2-((5-((E)-2-pyridin-4-ylvinyl) pyridin-3-yl)oxy)ethyl)amine | ABBOTT LABORATORIES | 2004-12-14 | — | — | US | claimed |