Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3552599 | 0.90 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3545951 | 0.90 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3547079 | 0.90 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| Valine SCHEMBL5757832 | 0.86 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3549106 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5793912 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3545145 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3544872 | 0.81 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5758337 | 0.81 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3539935 | 0.81 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435944-A1 | 4(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES | Memory Pharmaceutical Corporation (US) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032981-A1 | 4-(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES | MEMORY PHARMACEUTICALS CORPORATION (US) | 2003-04-24 | — | — | WO | disclosed |