SCHEMBL6854765

SCHEMBL6854765

OCC#Cc1ccc(-n2cncn2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
ALDH1A1 P00352 2/20 0.47
KDM4E B2RXH2 1/20 0.47
HSP90AA1 P07900 1/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
CYP2A6 P11509 1/20 0.40
FBP1 P09467 1/20 0.39
MELK Q14680 1/20 0.39
MMP2 P08253 1/20 0.36
MMP12 P39900 1/20 0.36
DPP4 P27487 2/20 0.36
SMYD3 Q9H7B4 1/20 0.36
PRMT5 O14744 1/20 0.36
WDR77 Q9BQA1 1/20 0.36
RAB9A P51151 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6851016 0.78 SMN1; SMN2 (0.51) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL3151931 0.78 SMN1; SMN2 (0.59) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL27905069 0.76 SMN1; SMN2 (0.72) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL6852729 0.74 KDM4E (0.60) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL6852136 0.74 NOTUM (0.50) ALDH1A1KDM4EMAPTMELKMMP2
SCHEMBL696687 0.74 SMN1; SMN2 (0.55) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL2270763 0.74 KDM4E (0.55) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL27967177 0.73 SMN1; SMN2 (0.58) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL6847759 0.73 QPCT (0.43) CYP1A2CYP2C9ALDH1A1KDM4EMELK
SCHEMBL19567209 0.72 SMN1; SMN2 (0.56) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed