SCHEMBL6857573

SCHEMBL6857573

Clc1ccc(CCOCc2ccc(Cl)cc2Cl)c(Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.58
ALDH1A1 P00352 1/20 0.48
HTT P42858 1/20 0.47
MAPK1 P28482 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
MRGPRX4 Q96LA9 1/20 0.47
NR4A2 P43354 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
CHRNB2 P17787 1/20 0.43
CHRNA4 P43681 1/20 0.43
INPPL1 O15357 1/20 0.41
NR4A1 P22736 1/20 0.41
NR4A3 Q92570 1/20 0.41
GAA P10253 1/20 0.41
S1PR4 O95977 1/20 0.41
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7888003 0.86 IDO1 (0.69) IDO1HTTMAPK1CYP1A2CYP3A4
SCHEMBL6732304 0.84 IDO1 (0.42) IDO1ALDH1A1HTTMAPK1CYP1A2
SCHEMBL28649281 0.84 IDO1 (0.62) IDO1HTTMAPK1CYP1A2CYP3A4
SCHEMBL10268366 0.83 IDO1 (0.56) IDO1ALDH1A1HTTMAPK1CYP1A2
SCHEMBL10636887 0.83 IDO1 (0.56) IDO1ALDH1A1HTTMAPK1CYP1A2
SCHEMBL22519886 0.81 HTT (0.61) IDO1ALDH1A1HTTMAPK1CYP1A2
SCHEMBL16681886 0.80 IDO1 (0.53) IDO1ALDH1A1HTTMAPK1CYP1A2
SCHEMBL22519847 0.79 HTT (0.54) IDO1ALDH1A1HTTMAPK1CYP1A2
SCHEMBL11621292 0.79 IDO1 (0.65) IDO1HTTMAPK1CYP1A2CYP3A4
SCHEMBL16770980 0.78 HTT (0.62) IDO1ALDH1A1HTTMAPK1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6790968-B1 ENHANCES ACTIVITY OF AZOLE ANTIFUNGAL AGENTS; TREATMENT OF DEEP-SEATED MYCOSIS; CULTURING TALAROMYCES FLAVUS THE KITASATO INSTITUTE (JP) 2004-09-14 US disclosed