Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855978 | 1.00 | PLK1 (0.34) | PLK1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL6850316 | 0.99 | PLK1 (0.35) | PLK1TSHRLMNAALDH1A1 | |
| SCHEMBL6850319 | 0.99 | PLK1 (0.35) | PLK1TSHRLMNAALDH1A1 | |
| SCHEMBL6856532 | 0.92 | PLK1 (0.38) | PLK1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL6856530 | 0.92 | PLK1 (0.38) | PLK1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL6855779 | 0.92 | PLK1 (0.38) | PLK1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL6856178 | 0.92 | PLK1 (0.38) | PLK1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL7538109 | 0.91 | MAPT (0.40) | PLK1TSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6850070 | 0.91 | PLK1 (0.39) | PLK1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL6850067 | 0.91 | PLK1 (0.39) | PLK1TSHRLMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | claimed |
| JP-2002543199-A | — | — | 2002-12-17 | — | — | JP | claimed |
| EP-1177195-A1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2002-02-06 | — | — | EP | claimed |
| WO-2000066584-A1 | 1-AMINO TRIAZOLO¢4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2000-11-09 | — | — | WO | claimed |
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | disclosed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |