Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 5/20 | 0.74 |
| ▸ | GSK3B | P49841 | 5/20 | 0.74 |
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163906 | 0.79 | BRAF (0.81) | GSK3AGSK3BBRAFMAPTMCL1 | |
| SCHEMBL3897840 | 0.75 | DUSP3 (0.73) | GSK3AGSK3BBRAFDUSP3MEN1 | |
| SCHEMBL3897845 | 0.75 | DUSP3 (0.73) | GSK3AGSK3BBRAFDUSP3MEN1 | |
| SCHEMBL4072823 | 0.74 | MAPT (0.68) | GSK3AGSK3BBRAFMAPTLMNA | |
| SCHEMBL1228305 | 0.74 | BRAF (0.60) | GSK3AGSK3BBRAFMAPTLMNA | |
| SCHEMBL1228309 | 0.74 | BRAF (0.60) | GSK3AGSK3BBRAFMAPTLMNA | |
| SCHEMBL5145115 | 0.73 | BRAF (0.68) | GSK3AGSK3BBRAFMAPTMCL1 | |
| SCHEMBL5145120 | 0.73 | BRAF (0.68) | GSK3AGSK3BBRAFMAPTMCL1 | |
| SCHEMBL1116150 | 0.72 | MAPT (0.69) | GSK3AGSK3BBRAFMAPTLMNA | |
| SCHEMBL5145368 | 0.72 | BRAF (0.82) | GSK3AGSK3BBRAFMAPTMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |