Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 8/20 | 0.63 |
| ▸ | CXCR2 | P25025 | 7/20 | 0.47 |
| ▸ | CX3CR1 | P49238 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6865162 | 0.92 | PAK4 (0.57) | PAK4CXCR2CX3CR1PPARGMEN1 | |
| SCHEMBL6865600 | 0.83 | PAK4 (0.69) | PAK4CXCR2CX3CR1PPARGMEN1 | |
| SCHEMBL5232402 | 0.82 | SMN1; SMN2 (0.48) | PAK4SMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL6864817 | 0.79 | PAK4 (0.63) | PAK4CXCR2CX3CR1PPARGLMNA | |
| SCHEMBL5236487 | 0.79 | PAK4 (0.74) | PAK4CXCR2CX3CR1PPARGSMN1; SMN2 | |
| SCHEMBL6859484 | 0.78 | CXCR2 (0.72) | CXCR2CX3CR1LMNAMEN1ALDH1A1 | |
| SCHEMBL6859474 | 0.78 | PAK4 (0.53) | PAK4CXCR2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6864976 | 0.78 | PAK4 (0.62) | PAK4CXCR2CX3CR1PPARGLMNA | |
| SCHEMBL212610 | 0.78 | PAK4 (1.00) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6864129 | 0.77 | CXCR2 (0.72) | CXCR2CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| EP-1104425-A1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009511-A1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-02-24 | — | — | WO | disclosed |