Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 6/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 5/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201838 | 0.89 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL656152 | 0.89 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL14703475 | 0.89 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL2200251 | 0.89 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL2200099 | 0.89 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL2200706 | 0.89 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL13620885 | 0.89 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL652170 | 0.87 | CCR1 (0.74) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL13620895 | 0.87 | CCR1 (0.74) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL13620880 | 0.87 | CCR1 (0.74) | CCR1CHRM2CCR5HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448566-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045942-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-06-05 | — | — | WO | disclosed |