Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.71 |
| ▸ | KDR | P35968 | 13/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.68 |
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | FLT3 | P36888 | 6/20 | 0.60 |
| ▸ | FLT4 | P35916 | 3/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | FLT1 | P17948 | 2/20 | 0.59 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.59 |
| ▸ | STK3 | Q13188 | 2/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.59 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.59 |
| ▸ | LATS1 | O95835 | 1/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6861551 | 1.00 | CHEK1 (0.71) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL26023377 | 0.86 | KDR (0.79) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL6855294 | 0.86 | KDR (0.67) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL6855290 | 0.86 | KDR (0.67) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL6672424 | 0.83 | CHEK1 (1.00) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL6672419 | 0.83 | CHEK1 (1.00) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL4410720 | 0.81 | KDR (1.00) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL4410717 | 0.81 | KDR (1.00) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL29363046 | 0.81 | KDR (1.00) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL4411073 | 0.80 | KDR (1.00) | CHEK1KDRFGFR1PDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6797825-B2 | 1,3-DIHYDRO-2H-INDOL- 2-ONE DERIVATIVES | ABBOTT LABORATORIES | 2004-09-28 | — | — | US | disclosed |
| US-20030162785-A1 | Protein kinase inhibitors | ABBVIE INC. | 2003-08-28 | — | — | US | disclosed |
| US-20030119839-A1 | Protein kinase inhibitors | ABBOTT LABORATORIES | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162785-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | CHEK1 139/4885KDR 1241/4885FGFR1 527/4885 |
| US-20030119839-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | CHEK1 139/4885KDR 1241/4885FGFR1 527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.