Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK7 | Q8TDX7 | 17/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | ABL2 | P42684 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869480 | 0.90 | NEK7 (0.46) | NEK7LCKABL1EGFRSRC | |
| SCHEMBL6870933 | 0.81 | NEK7 (0.52) | NEK7 | |
| SCHEMBL6461714 | 0.77 | RIPK2 (0.68) | LCKABL1EGFRSRCABL2 | |
| SCHEMBL6460259 | 0.76 | TEK (0.56) | NEK7 | |
| SCHEMBL6460401 | 0.76 | EIF2AK3 (0.49) | NEK7LCKABL1EGFRSRC | |
| SCHEMBL2074968 | 0.75 | SRC (0.48) | NEK7LCKABL1EGFRSRC | |
| SCHEMBL27088000 | 0.75 | NEK7 (0.64) | NEK7 | |
| SCHEMBL25253600 | 0.73 | NEK7 (0.69) | NEK7 | |
| SCHEMBL29999181 | 0.73 | NEK7 (0.67) | NEK7EGFR | |
| SCHEMBL29998751 | 0.73 | NEK7 (0.69) | NEK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713474-B2 | SERINE-THREONINE AND TYROSINE KINASE INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2004-03-30 | — | — | US | disclosed |
| CN-1335849-A | Pyrrolopyrimidines as protein kinase inhibitors | BASF AG (DE) | 2002-02-13 | — | — | CN | disclosed |