SCHEMBL6862684

SCHEMBL6862684

CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccncc1-c1ccccc1Cl

nearest known ligand 0.79

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 15/20 0.79
GPBAR1 Q8TDU6 5/20 0.63
TACR3 P29371 12/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6868998 0.99 TACR1 (0.77) TACR1GPBAR1TACR3
SCHEMBL1399482 0.92 TACR1 (0.79) TACR1GPBAR1TACR3
Hydrochloric Acid SCHEMBL6640269 0.91 TACR1 (0.77) TACR1GPBAR1TACR3
SCHEMBL6869637 0.88 TACR1 (1.00) TACR1GPBAR1
SCHEMBL6866148 0.88 TACR1 (0.80) TACR1GPBAR1TACR3
SCHEMBL6869459 0.88 TACR1 (0.80) TACR1GPBAR1TACR3
SCHEMBL6867420 0.88 TACR1 (0.73) TACR1GPBAR1TACR3
Hydrochloric Acid SCHEMBL6868501 0.87 TACR1 (0.98) TACR1GPBAR1
Hydrochloric Acid SCHEMBL6871057 0.87 TACR1 (0.79) TACR1GPBAR1TACR3
SCHEMBL6870864 0.85 TACR1 (0.76) TACR1GPBAR1TACR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1157005-B1 3-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2004-10-20 EP claimed
EP-1157005-A1 3-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2001-11-28 EP claimed
US-6225316-B1 GOOD AFFINITY TO THE NK-1 RECEPTOR. HOFFMANN-LA ROCHE INC. 2001-05-01 US claimed
WO-2000050401-A1 3-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2000-08-31 WO claimed
EP-1157005-B1 3-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2004-10-20 EP disclosed
EP-1157005-A1 3-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2001-11-28 EP disclosed
US-6225316-B1 GOOD AFFINITY TO THE NK-1 RECEPTOR. HOFFMANN-LA ROCHE INC. 2001-05-01 US disclosed
WO-2000050401-A1 3-PHENYLPYRIDINE DERIVATIVES AND THEIR USE AS NK-1 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2000-08-31 WO disclosed