Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 19/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863014 | 1.00 | CASR (0.62) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6857683 | 0.92 | CASR (0.60) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6857684 | 0.92 | CASR (0.60) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7558457 | 0.90 | CASR (0.67) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6864026 | 0.90 | CASR (0.67) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6857827 | 0.90 | CASR (0.67) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL6865617 | 0.89 | CASR (0.66) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL6865625 | 0.89 | CASR (0.66) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6858010 | 0.88 | CASR (0.47) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6858004 | 0.88 | CASR (0.47) | CASRSLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | claimed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | claimed |
| CN-1259120-A | Calcilytic compounds | SMITHKLINE BEECHAM CORP (US) | 2000-07-05 | — | — | CN | claimed |
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| CN-1290174-A | Compositions and methods for systemic delivery of oral vaccines and therapeutics | UNIV JEFFERSON (US) | 2001-04-04 | — | — | CN | disclosed |
| CN-1259120-A | Calcilytic compounds | SMITHKLINE BEECHAM CORP (US) | 2000-07-05 | — | — | CN | disclosed |