Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 20/20 | 1.00 |
| ▸ | MAPK9 | P45984 | 9/20 | 1.00 |
| ▸ | MAPK10 | P53779 | 9/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163195 | 1.00 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL6862451 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1200506 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1163009 | 0.87 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1200959 | 0.87 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL6876597 | 0.85 | MAPK8 (0.84) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14834311 | 0.82 | MAPK8 (0.79) | MAPK8MAPK9MAPK10 | |
| SCHEMBL15457491 | 0.82 | MAPK8 (0.79) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14175975 | 0.81 | MAPK8 (0.69) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14768122 | 0.81 | MAPK8 (0.69) | MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536172-B2 | Inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536172-B2 | Inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2013-09-17 | — | — | US | disclosed |
| WO-2011018417-A1 | INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-02-17 | — | — | WO | disclosed |
| US-20110034470-A1 | Inhibitors of JNK | GONG LEYI | 2011-02-10 | — | — | US | disclosed |
| US-20110034470-A1 | Inhibitors of JNK | GONG LEYI | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034470-A1 | Inhibitors of JNK | MAPK1, MAP3K6, MAP3K3 | MAPK8 32/4885MAPK9 25/4885MAPK10 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.