Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 14/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842322 | 0.89 | CXCR2 (0.70) | CXCR2CXCR1 | |
| SCHEMBL4236680 | 0.84 | CXCR2 (0.57) | CXCR2HPGDKMT2A | |
| SCHEMBL6863822 | 0.84 | CXCR2 (0.56) | CXCR2CXCR1 | |
| SCHEMBL6865630 | 0.81 | CXCR2 (0.47) | CXCR2HPGDGAAKMT2A | |
| SCHEMBL6866758 | 0.80 | MEN1 (0.57) | CXCR2HPGDGAAKMT2A | |
| SCHEMBL6868880 | 0.80 | CXCR2 (0.47) | CXCR2HPGDGAAKMT2A | |
| SCHEMBL6866799 | 0.80 | CXCR2 (0.47) | CXCR2HPGDGAAKMT2A | |
| SCHEMBL6868931 | 0.80 | CXCR2 (0.47) | CXCR2KMT2A | |
| SCHEMBL841338 | 0.77 | CXCR2 (0.66) | CXCR2 | |
| SCHEMBL6997947 | 0.77 | CXCR2 (0.56) | CXCR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | claimed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |