Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 3/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069065 | 0.82 | KMT2A (0.61) | KMT2AMEN1HSD11B1NPSR1F2 | |
| SCHEMBL2061708 | 0.78 | KMT2A (0.65) | KMT2AMEN1HSD11B1F2PRSS1 | |
| SCHEMBL30498944 | 0.78 | KMT2A (0.65) | KMT2AMEN1HSD11B1F2PRSS1 | |
| SCHEMBL1025251 | 0.78 | KMT2A (0.53) | KMT2AMEN1HSD11B1NPSR1F2 | |
| SCHEMBL1024682 | 0.76 | KMT2A (0.51) | KMT2AMEN1HSD11B1NPSR1F2 | |
| SCHEMBL819388 | 0.75 | KMT2A (0.63) | KMT2AMEN1F2PRSS1PRSS2 | |
| SCHEMBL30286885 | 0.75 | KMT2A (0.47) | KMT2AMEN1HSD11B1NPSR1F2 | |
| SCHEMBL7226710 | 0.74 | KMT2A (0.60) | KMT2AMEN1NPSR1F2PRSS1 | |
| SCHEMBL1026059 | 0.74 | KMT2A (0.68) | KMT2AMEN1HSD11B1NPSR1F2 | |
| SCHEMBL15609680 | 0.74 | KMT2A (0.62) | KMT2AMEN1HSD11B1NPSR1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800444-B1 | USEFUL AS ANTIBACTERIAL AND OTHER PHARMACEUTICAL AGENTS/INTERMEDIATES | ISIS PHARMACEUTICALS, INC. | 2004-10-05 | — | — | US | disclosed |
| US-5780241-A | ALTERING ELECTROCHEMICAL PROPERTIES BY DECYCLIZATION | ISIS PHARMACEUTICALS, INC. (US) | 1998-07-14 | — | — | US | disclosed |
| WO-1998020349-A1 | COMPLEX CHEMICAL LIBRARIES | ISIS PHARMACEUTICALS, INC. (US) | 1998-05-14 | — | — | WO | disclosed |