Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.57 |
| ▸ | PDE4A | P27815 | 5/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532404 | 1.00 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DRORC | |
| SCHEMBL5355633 | 1.00 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DRORC | |
| SCHEMBL5354769 | 0.94 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DRORC | |
| SCHEMBL4538071 | 0.90 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5355845 | 0.90 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL4538042 | 0.90 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5350722 | 0.90 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DRORC | |
| SCHEMBL5792320 | 0.89 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DRORC | |
| SCHEMBL5792469 | 0.89 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DRORC | |
| SCHEMBL5757290 | 0.89 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716871-B2 | OBESITY; INFLAMMATORY DISEASES, DISEASES INVOLVING ELEVATED LEVELS OF CYTOKINES, CENTRAL NERVOUS SYSTEM DISORDERS; 3-HYDROXYALKYL-4-DIALKOXYPHENYL-SUBSTITUTED PYRROLIDINES | ICOS CORPORATION | 2004-04-06 | — | — | US | disclosed |