Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6698134 | 0.90 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6670099 | 0.78 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6669059 | 0.73 | MAPK14 (0.89) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3305280 | 0.73 | MAPK14 (1.00) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6667801 | 0.73 | MAPK14 (0.75) | MAPK14MAPK11 | |
| SCHEMBL6667200 | 0.72 | MAPK14 (0.56) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL14201945 | 0.70 | MAPK14 (0.77) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6667321 | 0.69 | MAPK14 (0.62) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6667983 | 0.69 | MAPK14 (0.88) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6667601 | 0.68 | MAPK14 (0.61) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809199-B2 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES | MERCK & CO., INC. | 2004-10-26 | — | — | US | disclosed |
| WO-2002058695-A9 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO INC (US) | 2003-09-12 | — | — | WO | disclosed |
| US-20030092712-A1 | (Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092712-A1 | (Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents | MAPK1, MAPK7, MAPKAPK2 | MAPK14 5/4885MAPK11 8/4885MAPK13 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.