Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859846 | 0.80 | MAPK14 (0.58) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL4181561 | 0.79 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL4463596 | 0.78 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL14201929 | 0.77 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL6668637 | 0.74 | MAPK14 (0.70) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL4174284 | 0.73 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL4485577 | 0.73 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL1059157 | 0.72 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL6671359 | 0.72 | MAPK14 (1.00) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL6666576 | 0.71 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809199-B2 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES | MERCK & CO., INC. | 2004-10-26 | — | — | US | disclosed |