Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.37 |
| ▸ | ENO1 | P06733 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867058 | 1.00 | MCHR1 (0.47) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL7041689 | 0.92 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6874118 | 0.91 | MCHR1 (0.49) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6457583 | 0.90 | MCHR1 (0.52) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6457572 | 0.90 | MCHR1 (0.52) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6456447 | 0.89 | EPHX2 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6456440 | 0.89 | EPHX2 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6868725 | 0.88 | MCHR1 (0.58) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6868729 | 0.88 | MCHR1 (0.58) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6871988 | 0.87 | MCHR1 (0.44) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |