Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867250 | 1.00 | MCHR1 (0.45) | MCHR1ADRA2AADRA1AHTR2BHTR1A | |
| SCHEMBL6874476 | 0.84 | MCHR1 (0.44) | MCHR1ADRA2AADRA1AHTR2BHTR1A | |
| SCHEMBL6874481 | 0.84 | MCHR1 (0.44) | MCHR1ADRA2AADRA1AHTR2BHTR1A | |
| SCHEMBL6873319 | 0.83 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHTR1A | |
| SCHEMBL6873323 | 0.83 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHTR1A | |
| SCHEMBL7046703 | 0.82 | MCHR1 (0.51) | MCHR1ADRA2AADRA1AHTR2BHTR1A | |
| SCHEMBL7046707 | 0.82 | MCHR1 (0.51) | MCHR1ADRA2AADRA1AHTR2BHTR1A | |
| SCHEMBL6466329 | 0.81 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHTR1A | |
| SCHEMBL6466322 | 0.81 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHTR1A | |
| SCHEMBL6869172 | 0.80 | CNR1 (0.45) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |