Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.75 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.75 |
| ▸ | IGF1R | P08069 | 7/20 | 0.75 |
| ▸ | ERBB3 | P21860 | 7/20 | 0.75 |
| ▸ | TEK | Q02763 | 3/20 | 0.58 |
| ▸ | HCK | P08631 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867295 | 1.00 | EGFR (0.75) | EGFRERBB2ERBB4IGF1RERBB3 | |
| SCHEMBL6462308 | 0.88 | EGFR (0.73) | EGFRERBB2ERBB4IGF1RERBB3 | |
| SCHEMBL6461130 | 0.88 | EGFR (0.73) | EGFRERBB2ERBB4IGF1RERBB3 | |
| SCHEMBL6461141 | 0.88 | EGFR (0.73) | EGFRERBB2ERBB4IGF1RERBB3 | |
| SCHEMBL5801987 | 0.86 | EGFR (0.84) | EGFRERBB2ERBB4IGF1RERBB3 | |
| SCHEMBL6430378 | 0.86 | EGFR (0.84) | EGFRERBB2ERBB4IGF1RERBB3 | |
| SCHEMBL4826480 | 0.86 | EGFR (0.84) | EGFRERBB2ERBB4IGF1RERBB3 | |
| SCHEMBL6107993 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB4IGF1RERBB3 | |
| SCHEMBL6107989 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB4IGF1RERBB3 | |
| SCHEMBL6108340 | 0.85 | EGFR (0.84) | EGFRERBB2ERBB4IGF1RERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713474-B2 | SERINE-THREONINE AND TYROSINE KINASE INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2004-03-30 | — | — | US | disclosed |
| US-20030153752-A1 | Pyrrolopyrimidines as therapeutic agents | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2003-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153752-A1 | Pyrrolopyrimidines as therapeutic agents | FLT1, FLT4, TFPI | EGFR 457/4885ERBB2 341/4885ERBB4 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.