Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.58 |
| ▸ | ACHE | P22303 | 5/20 | 0.50 |
| ▸ | BCHE | P06276 | 4/20 | 0.50 |
| ▸ | BACE1 | P56817 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867434 | 1.00 | MCHR1 (0.58) | MCHR1ACHEBCHEBACE1KDM4E | |
| SCHEMBL6877755 | 0.91 | MCHR1 (0.55) | MCHR1ACHEBCHEBACE1KDM4E | |
| SCHEMBL6877736 | 0.91 | MCHR1 (0.55) | MCHR1ACHEBCHEBACE1KDM4E | |
| SCHEMBL6867620 | 0.89 | MCHR1 (0.49) | MCHR1ACHEBCHEBACE1KDM4E | |
| SCHEMBL6867626 | 0.89 | MCHR1 (0.49) | MCHR1ACHEBCHEBACE1KDM4E | |
| SCHEMBL6866792 | 0.88 | MCHR1 (0.58) | MCHR1ACHEBCHEKDM4EALDH1A1 | |
| SCHEMBL6866791 | 0.88 | MCHR1 (0.58) | MCHR1ACHEBCHEKDM4EALDH1A1 | |
| SCHEMBL6873483 | 0.88 | MCHR1 (0.54) | MCHR1ACHEBCHEAPP | |
| SCHEMBL6873479 | 0.88 | MCHR1 (0.54) | MCHR1ACHEBCHEAPP | |
| SCHEMBL6868072 | 0.87 | MCHR1 (0.51) | MCHR1ACHEBCHEBACE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |