Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 6/20 | 0.48 |
| ▸ | CNR1 | P21554 | 5/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | HTR2B | P41595 | 4/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867507 | 1.00 | MCHR1 (0.55) | MCHR1ALDH1A1CNR2CNR1ADRA2A | |
| SCHEMBL6877869 | 0.88 | MCHR1 (0.62) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6877875 | 0.88 | MCHR1 (0.62) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6455835 | 0.86 | MCHR1 (0.54) | MCHR1CNR2CNR1ADRA2AHRH1 | |
| SCHEMBL6877143 | 0.81 | MCHR1 (0.67) | MCHR1ALDH1A1ADRA2AHRH1HTR2B | |
| SCHEMBL6877135 | 0.81 | MCHR1 (0.67) | MCHR1ALDH1A1ADRA2AHRH1HTR2B | |
| Trifluoroacetic Acid SCHEMBL6461882 | 0.80 | MCHR1 (0.56) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6463413 | 0.80 | MCHR1 (0.60) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6463408 | 0.80 | MCHR1 (0.60) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6457337 | 0.80 | MCHR1 (0.65) | MCHR1CNR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |