Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 9/20 | 0.50 |
| ▸ | DNMT3A | Q9Y6K1 | 7/20 | 0.50 |
| ▸ | DNMT3L | Q9UJW3 | 4/20 | 0.50 |
| ▸ | AURKA | O14965 | 6/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.45 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.45 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.45 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | SIK1 | P57059 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13553269 | 0.95 | DNMT1 (0.48) | DNMT1DNMT3ADNMT3LAURKAAURKB | |
| SCHEMBL683733 | 0.83 | DNMT1 (0.50) | DNMT1DNMT3ADNMT3LAURKAAURKB | |
| SCHEMBL683853 | 0.83 | DNMT1 (0.49) | DNMT1DNMT3ADNMT3LAURKAAURKB | |
| SCHEMBL682916 | 0.78 | DNMT1 (0.60) | DNMT1DNMT3ADNMT3LAURKAAURKB | |
| SCHEMBL678697 | 0.75 | DNMT1 (0.58) | DNMT1DNMT3ADNMT3LAURKAAURKB | |
| SCHEMBL682918 | 0.73 | MCHR1 (0.49) | DNMT1DNMT3ADNMT3LAURKAAURKB | |
| SCHEMBL684429 | 0.72 | MCHR1 (0.54) | DNMT1DNMT3ADNMT3L | |
| SCHEMBL3454444 | 0.71 | AURKA (0.66) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL3454464 | 0.71 | AURKA (0.66) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL12639295 | 0.71 | DNMT1 (0.65) | DNMT1DNMT3ADNMT3LAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269758-A1 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| WO-2010002779-A2 | NAPHTHYRIDININONES AS AURORA KINASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269758-A1 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS | AURKA, AURKC, AURKB | DNMT1 1209/4885DNMT3A 2101/4885DNMT3L 2202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.