SCHEMBL6867547 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	MAPT	P10636	2/20	0.47

▸	MCHR1	Q99705	13/20	0.44

▸	ADRA2A	P08913	9/20	0.44

▸	HRH1	P35367	6/20	0.44

▸	HTR2B	P41595	6/20	0.44

▸	ADRA1A	P35348	3/20	0.44

▸	HTT	P42858	2/20	0.38

▸	NPC1	O15118	2/20	0.38

▸	RAB9A	P51151	2/20	0.38

▸	ALDH1A1	P00352	1/20	0.38

▸	KMT2A	Q03164	1/20	0.38

▸	TSHR	P16473	2/20	0.37

▸	SMN1; SMN2	Q16637	2/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6867543	1.00	MAPT (0.47)	MAPTMCHR1ADRA2AHRH1HTR2B
SCHEMBL6868122	0.92	MCHR1 (0.46)	MAPTMCHR1ADRA2AHRH1HTR2B
SCHEMBL6868128	0.92	MCHR1 (0.46)	MAPTMCHR1ADRA2AHRH1HTR2B
SCHEMBL7113893	0.92	MCHR1 (0.46)	MAPTMCHR1ADRA2AHRH1HTR2B
SCHEMBL7113885	0.92	MCHR1 (0.46)	MAPTMCHR1ADRA2AHRH1HTR2B
SCHEMBL6877519	0.90	MCHR1 (0.46)	MAPTMCHR1ADRA2AHRH1HTR2B
SCHEMBL6877515	0.90	MCHR1 (0.46)	MAPTMCHR1ADRA2AHRH1HTR2B
SCHEMBL6872929	0.89	MCHR1 (0.48)	MCHR1ADRA2AHRH1HTR2BADRA1A
SCHEMBL6872925	0.89	MCHR1 (0.48)	MCHR1ADRA2AHRH1HTR2BADRA1A
SCHEMBL6832112	0.89	MCHR1 (0.44)	MAPTMCHR1ADRA2AHRH1HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1464335-A2	Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist	Taisho Pharmaceutical Co. Ltd. (JP)	2004-10-06	—	—	EP	disclosed