Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | HTR2B | P41595 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24087673 | 0.77 | AGXT (0.64) | AGXTLOXL2HTR1ADRD2HTR2B | |
| SCHEMBL5396026 | 0.75 | HDAC6 (0.41) | AGXTLOXL2 | |
| SCHEMBL6867695 | 0.74 | MAOB (0.50) | AGXT | |
| SCHEMBL445222 | 0.74 | SMN1; SMN2 (0.42) | LOXL2 | |
| SCHEMBL7342156 | 0.74 | POLB (0.34) | AGXTLOXL2 | |
| SCHEMBL6871889 | 0.72 | MAOB (0.49) | — | |
| SCHEMBL6871886 | 0.71 | AGXT (0.37) | AGXTP2RX3HTR1ADRD2HTR2B | |
| SCHEMBL1096394 | 0.70 | HTR2B (0.40) | AGXTLOXL2HTR1ADRD2HTR2B | |
| SCHEMBL6869618 | 0.69 | AKR1B1 (0.48) | — | |
| SCHEMBL767149 | 0.69 | DYRK1A (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149094-B1 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | BASILEA PHARMACEUTICA AG (CH) | 2004-04-21 | — | — | EP | disclosed |
| US-6376491-B1 | BENZOFURAN DERIVATIVES FOR TREATMENT OR PREVENTION OF MYCOSIS IN MAMMALS | BASILEA PHARMACEUTICA AG (CH) | 2002-04-23 | — | — | US | disclosed |
| EP-1149094-A2 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | Basilea Pharmaceutica AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000037464-A2 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | BASILEA PHARMACEUTICA AG (CH) | 2000-06-29 | — | — | WO | disclosed |