Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.67 |
| ▸ | HTR2B | P41595 | 2/20 | 0.67 |
| ▸ | HRH1 | P35367 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867985 | 1.00 | MCHR1 (0.69) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6872145 | 0.93 | MCHR1 (0.69) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6872150 | 0.93 | MCHR1 (0.69) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6464738 | 0.93 | MCHR1 (0.77) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6464732 | 0.93 | MCHR1 (0.77) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| Hydrochloric Acid SCHEMBL6458209 | 0.92 | MCHR1 (0.75) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| Hydrochloric Acid SCHEMBL6458202 | 0.92 | MCHR1 (0.75) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6877048 | 0.88 | MCHR1 (0.65) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6877057 | 0.88 | MCHR1 (0.65) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6878099 | 0.88 | MCHR1 (0.88) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |