Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868117 | 1.00 | POLB (0.56) | POLBMCHR1ADRA2AADRA1AHTR2B | |
| SCHEMBL6458599 | 0.88 | MCHR1 (0.65) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6458588 | 0.88 | MCHR1 (0.65) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6879751 | 0.87 | MCHR1 (0.59) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6879759 | 0.87 | MCHR1 (0.59) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875149 | 0.86 | MCHR1 (0.55) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6868624 | 0.86 | MCHR1 (0.55) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6868631 | 0.86 | MCHR1 (0.55) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875143 | 0.86 | MCHR1 (0.55) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6868862 | 0.85 | MCHR1 (0.56) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |