Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 19/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 15/20 | 0.51 |
| ▸ | HRH1 | P35367 | 7/20 | 0.48 |
| ▸ | HTR2B | P41595 | 6/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868300 | 1.00 | MCHR1 (0.51) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462831 | 0.88 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462840 | 0.88 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6459116 | 0.86 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462962 | 0.86 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6868116 | 0.86 | MCHR1 (0.56) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6868112 | 0.86 | MCHR1 (0.56) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6456877 | 0.85 | MCHR1 (0.49) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462789 | 0.85 | MCHR1 (0.71) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6458601 | 0.85 | MCHR1 (0.71) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |