Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.55 |
| ▸ | HTR2B | P41595 | 6/20 | 0.55 |
| ▸ | HRH1 | P35367 | 5/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868629 | 1.00 | MCHR1 (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6458818 | 0.89 | MCHR1 (0.65) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6458824 | 0.89 | MCHR1 (0.65) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6459831 | 0.88 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6459836 | 0.88 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6459371 | 0.84 | MCHR1 (0.51) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6459376 | 0.84 | MCHR1 (0.51) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6456621 | 0.83 | MCHR1 (0.52) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6456628 | 0.83 | MCHR1 (0.52) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6457366 | 0.82 | MCHR1 (0.49) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |