Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30668778 | 0.84 | METAP1 (0.56) | METAP1NAMPTRXFP1ATRTDP2 | |
| SCHEMBL15266282 | 0.84 | METAP1 (0.56) | METAP1NAMPTRXFP1ATRTDP2 | |
| SCHEMBL2392457 | 0.84 | METAP1 (0.56) | METAP1NAMPTRXFP1ATRTDP2 | |
| SCHEMBL3243855 | 0.84 | METAP1 (0.56) | METAP1NAMPTRXFP1ATRTDP2 | |
| SCHEMBL22556188 | 0.84 | TDP1 (0.61) | METAP1POLBLMNAMEN1KMT2A | |
| SCHEMBL393203 | 0.83 | METAP1 (0.55) | METAP1NAMPTRXFP1ATRTDP2 | |
| SCHEMBL21567565 | 0.83 | METAP1 (0.55) | METAP1NAMPTRXFP1ATRTDP2 | |
| SCHEMBL1699207 | 0.83 | ATR (0.56) | METAP1ATRPOLBLMNAMEN1 | |
| SCHEMBL2363495 | 0.83 | METAP1 (0.55) | METAP1NAMPTRXFP1ATRTDP2 | |
| SCHEMBL1580424 | 0.83 | METAP1 (0.55) | METAP1NAMPTRXFP1ATRTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119694-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |