Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 6/20 | 0.77 |
| ▸ | CXCR2 | P25025 | 11/20 | 0.66 |
| ▸ | CX3CR1 | P49238 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212610 | 0.87 | PAK4 (1.00) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6865910 | 0.82 | CXCR2 (0.63) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6864490 | 0.82 | PAK4 (0.78) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6866720 | 0.81 | CXCR2 (0.90) | CXCR2CX3CR1 | |
| SCHEMBL6859464 | 0.81 | CXCR2 (0.72) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6866078 | 0.80 | CXCR2 (0.75) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6859586 | 0.80 | CXCR2 (0.71) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6866174 | 0.80 | CXCR2 (0.81) | CXCR2CX3CR1 | |
| SCHEMBL6866187 | 0.80 | CXCR2 (0.70) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6868599 | 0.80 | CXCR2 (1.00) | PAK4CXCR2CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |