Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.38 |
| ▸ | PDE4A | P27815 | 8/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869157 | 1.00 | PDE4B (0.38) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6869160 | 1.00 | PDE4B (0.38) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6871724 | 0.91 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6870965 | 0.91 | PDE4B (0.40) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6870961 | 0.91 | PDE4B (0.40) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6870967 | 0.91 | PDE4B (0.40) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6871720 | 0.91 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6871721 | 0.91 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6867957 | 0.87 | PDE4B (0.32) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6867953 | 0.87 | PDE4B (0.32) | PDE4BPDE4APDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095040-B1 | NEW BENZOXAZOLES WITH PDE-INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2004-03-31 | — | — | EP | disclosed |
| EP-1095040-A1 | NEW BENZOXAZOLES WITH PDE-INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001695-A1 | NEW BENZOXAZOLES WITH PDE-INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-01-13 | — | — | WO | disclosed |