Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 4/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 13/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.44 |
| ▸ | HRH1 | P35367 | 5/20 | 0.44 |
| ▸ | HTR2B | P41595 | 5/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869351 | 1.00 | EPHX1 (0.46) | EPHX1LCKMCHR1ADRA2AHRH1 | |
| SCHEMBL6879572 | 0.95 | MCHR1 (0.44) | EPHX1LCKMCHR1ADRA2AHRH1 | |
| SCHEMBL6879578 | 0.95 | MCHR1 (0.44) | EPHX1LCKMCHR1ADRA2AHRH1 | |
| SCHEMBL6879285 | 0.93 | EPHX1 (0.53) | EPHX1LCKMCHR1ADRA2AHRH1 | |
| SCHEMBL6879288 | 0.93 | EPHX1 (0.53) | EPHX1LCKMCHR1ADRA2AHRH1 | |
| SCHEMBL6463027 | 0.89 | MCHR1 (0.46) | LCKMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6463030 | 0.89 | MCHR1 (0.46) | LCKMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6872737 | 0.88 | SMN1; SMN2 (0.56) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6872741 | 0.88 | SMN1; SMN2 (0.56) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462544 | 0.88 | EPHX1 (0.45) | EPHX1MCHR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |