Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669858 | 0.81 | CHRM5 (0.41) | MAPK14MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL6672647 | 0.71 | MAPK14 (0.48) | MAPK14MEN1KMT2AMAPTCHRM5 | |
| SCHEMBL6870151 | 0.70 | MAPK14 (0.62) | POLBMAPK14MEN1KMT2ATSHR | |
| SCHEMBL6867107 | 0.69 | MAPK14 (0.49) | POLBMAPK14MEN1KMT2ATSHR | |
| SCHEMBL6670558 | 0.68 | CHRM5 (0.47) | MAPK14MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6670174 | 0.65 | MAPK14 (0.54) | POLBMAPK14MEN1KMT2AALOX5 | |
| SCHEMBL6668375 | 0.65 | CHRM5 (0.43) | MAPK14MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6668033 | 0.65 | CHRM5 (0.43) | MAPK14MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6668342 | 0.64 | MAPK14 (0.73) | MAPK14 | |
| SCHEMBL6643544 | 0.63 | MAPK14 (0.47) | MAPK14ALDH1A1SMN1; SMN2CHRM5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809199-B2 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES | MERCK & CO., INC. | 2004-10-26 | — | — | US | disclosed |