Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.72 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5620255 | 0.84 | PARP1 (1.00) | PARP1PARP2 | |
| Hydrochloric Acid SCHEMBL18614474 | 0.83 | PARP1 (0.98) | PARP1PARP2 | |
| SCHEMBL6872852 | 0.82 | PARP1 (0.72) | PARP1PARP2 | |
| SCHEMBL6872354 | 0.81 | PARP1 (0.70) | PARP1PARP2 | |
| SCHEMBL6874969 | 0.77 | PARP1 (0.51) | PARP1 | |
| SCHEMBL6869690 | 0.76 | PARP1 (0.62) | PARP1PARP2 | |
| SCHEMBL6873574 | 0.76 | PARP1 (0.73) | PARP1PARP2 | |
| SCHEMBL1298068 | 0.76 | PARP1 (0.64) | PARP1PARP2 | |
| SCHEMBL6870155 | 0.76 | PARP1 (0.62) | PARP1PARP2 | |
| SCHEMBL6873107 | 0.75 | PARP1 (0.71) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |