Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 11/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688164 | 0.94 | MAPT (0.41) | MAPTPTGER3THRBCYP1A2KDM4E | |
| SCHEMBL688306 | 0.92 | MAPT (0.51) | MAPTPTGER3THRBMMP12KDM4E | |
| SCHEMBL688178 | 0.92 | PTGER3 (0.42) | MAPTPTGER3CYP1A2KDM4EALDH1A1 | |
| SCHEMBL687117 | 0.90 | PTGER3 (0.52) | MAPTPTGER3CYP1A2KDM4EALDH1A1 | |
| SCHEMBL27741944 | 0.89 | CTSA (0.47) | MAPTPTGER3WDR5THRBKDM4E | |
| SCHEMBL687768 | 0.89 | CTSA (0.47) | MAPTPTGER3WDR5THRBKDM4E | |
| SCHEMBL687597 | 0.89 | PTGER3 (0.46) | PTGER3CYP1A2SLC16A3SLC16A1MCTS1 | |
| SCHEMBL687654 | 0.88 | PTGER3 (0.43) | MAPTPTGER3CYP1A2KDM4EALDH1A1 | |
| SCHEMBL686873 | 0.88 | PTGER3 (0.49) | PTGER3CYP1A2KDM4EALDH1A1MAPK1 | |
| SCHEMBL687152 | 0.88 | PTGER3 (0.48) | PTGER3CYP1A2KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |