Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 12/20 | 0.84 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.84 |
| ▸ | BUB1 | O43683 | 1/20 | 0.79 |
| ▸ | PRKACG | P22612 | 1/20 | 0.79 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.79 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.79 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.79 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407363 | 0.91 | MAPK14 (1.00) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3405486 | 0.90 | MAPK14 (0.87) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3409067 | 0.90 | MAPK14 (0.82) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3429198 | 0.90 | MAPK14 (0.78) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3427536 | 0.90 | MAPK14 (0.84) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3431414 | 0.89 | MAPK14 (0.82) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3426933 | 0.89 | MAPK14 (0.78) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| Losmapimod SCHEMBL29367949 | 0.89 | MAPK14 (1.00) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| Losmapimod SCHEMBL1070401 | 0.89 | MAPK14 (1.00) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| Losmapimod SCHEMBL29888732 | 0.89 | MAPK14 (1.00) | MAPK14CYP2C9MAPK11BUB1PRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3691620-A1 | P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD | Fulcrum Therapeutics, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019071147-A1 | P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD | Fulcrum Therapeutics, Inc. (US) | 2019-04-11 | — | — | WO | disclosed |
| EP-1474395-A1 | NICOTINAMIDE DERIVATES USEFUL AS P38 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003068747-A1 | NICOTINAMIDE DERIVATES USEFUL AS P38 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |