Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.73 |
| ▸ | MTOR | P42345 | 3/20 | 0.66 |
| ▸ | BLK | P51451 | 3/20 | 0.66 |
| ▸ | BMX | P51813 | 3/20 | 0.66 |
| ▸ | JAK3 | P52333 | 3/20 | 0.66 |
| ▸ | BTK | Q06187 | 3/20 | 0.66 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
| ▸ | CLK2 | P49760 | 1/20 | 0.66 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | TEC | P42680 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873387 | 0.90 | PIK3CA (0.64) | PIK3CAMTORBLKBMXJAK3 | |
| SCHEMBL6874084 | 0.89 | PIK3CA (0.73) | PIK3CAMTORBLKBMXJAK3 | |
| SCHEMBL6876324 | 0.87 | PIK3CA (0.72) | PIK3CAMTORBLKBMXJAK3 | |
| SCHEMBL6874867 | 0.87 | PIK3CA (0.78) | PIK3CA | |
| SCHEMBL6875922 | 0.87 | PIK3CA (0.78) | PIK3CAMTORBLKBMXJAK3 | |
| SCHEMBL6875478 | 0.86 | PIK3CA (0.82) | PIK3CAMTORBLKBMXJAK3 | |
| SCHEMBL11885744 | 0.85 | PIK3CA (0.79) | PIK3CA | |
| SCHEMBL6874865 | 0.85 | PIK3CA (0.69) | PIK3CA | |
| SCHEMBL6877121 | 0.85 | PIK3CA (0.79) | PIK3CAMTORMKNK2 | |
| SCHEMBL7912460 | 0.85 | MTOR (0.67) | PIK3CAMTORBLKBMXJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180185374-A1 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2018-07-05 | — | — | US | disclosed |
| US-20180185374-A1 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2018-07-05 | — | — | US | disclosed |
| US-8889706-B2 | Soluble mTOR complexes and modulators thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889706-B2 | Soluble mTOR complexes and modulators thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140018354-A9 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | KADMON CORPORATION, LLC | 2014-01-16 | — | — | US | disclosed |
| US-20140018354-A9 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | KADMON CORPORATION, LLC | 2014-01-16 | — | — | US | disclosed |
| US-20130072485-A1 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072485-A1 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| US-8394818-B2 | Soluble mTOR complexes and modulators thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-03-12 | — | — | US | disclosed |
| US-8394818-B2 | Soluble mTOR complexes and modulators thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20120190676-A1 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | MOORMAN NATHANIEL (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190676-A1 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | MOORMAN NATHANIEL (US) | 2012-07-26 | — | — | US | disclosed |
| US-20110288091-A1 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288091-A1 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2011-11-24 | — | — | US | disclosed |
| WO-2011011716-A1 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |
| WO-2010044885-A2 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190676-A1 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | EIF2AK2, MTOR, EIF4EBP1 | PIK3CA 501/4885MTOR 2/4885BLK 1195/4885 |
| US-20130072485-A1 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | MTOR, RICTOR, RPTOR | PIK3CA 36/4885MTOR 1/4885BLK 1714/4885 |
| US-20180185374-A1 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | EIF2AK2, MTOR, EIF4EBP1 | PIK3CA 501/4885MTOR 2/4885BLK 1195/4885 |
| US-20140018354-A9 | INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS | EIF2AK2, MTOR, EIF4EBP1 | PIK3CA 501/4885MTOR 2/4885BLK 1195/4885 |
| US-20110288091-A1 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | MTOR, RICTOR, RPTOR | PIK3CA 36/4885MTOR 1/4885BLK 1714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.