Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.66 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873881 | 1.00 | MCHR1 (0.66) | MCHR1CNR1KCNH2AURKBADRA2A | |
| SCHEMBL6877369 | 0.92 | MCHR1 (0.61) | MCHR1CNR1KCNH2AURKBADRA2A | |
| SCHEMBL6877375 | 0.92 | MCHR1 (0.61) | MCHR1CNR1KCNH2AURKBADRA2A | |
| SCHEMBL6869069 | 0.91 | MCHR1 (0.64) | MCHR1CNR1KCNH2AURKBADRA2A | |
| SCHEMBL6869074 | 0.91 | MCHR1 (0.64) | MCHR1CNR1KCNH2AURKBADRA2A | |
| SCHEMBL6462045 | 0.89 | MCHR1 (0.65) | MCHR1CNR1KCNH2AURKBADRA2A | |
| SCHEMBL6462040 | 0.89 | MCHR1 (0.65) | MCHR1CNR1KCNH2AURKBADRA2A | |
| SCHEMBL6874709 | 0.87 | MCHR1 (0.58) | MCHR1CNR1KCNH2AURKBADRA2A | |
| SCHEMBL6874713 | 0.87 | MCHR1 (0.58) | MCHR1CNR1KCNH2AURKBADRA2A | |
| SCHEMBL6868296 | 0.86 | MCHR1 (0.54) | MCHR1CNR1KCNH2AURKBADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |