Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874591 | 1.00 | MAPK14 (0.58) | MAPK14MAPK8KDM4ENTRK1MAPT | |
| SCHEMBL6877761 | 0.90 | MAPK14 (0.54) | MAPK14MAPK8KDM4ENTRK1NPSR1 | |
| SCHEMBL6877769 | 0.90 | MAPK14 (0.54) | MAPK14MAPK8KDM4ENTRK1NPSR1 | |
| SCHEMBL6867288 | 0.87 | MAPK8 (0.48) | MAPK14MAPK8KDM4EMAPTMCHR1 | |
| SCHEMBL6867297 | 0.87 | MAPK8 (0.48) | MAPK14MAPK8KDM4EMAPTMCHR1 | |
| SCHEMBL4035067 | 0.82 | MCHR1 (0.56) | MAPK14MAPK8KDM4EMCHR1ADRA2A | |
| SCHEMBL4035066 | 0.82 | MCHR1 (0.56) | MAPK14MAPK8KDM4EMCHR1ADRA2A | |
| SCHEMBL6873229 | 0.81 | EPHX1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6873237 | 0.81 | EPHX1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6461522 | 0.80 | MAPK8 (0.46) | MAPK14MAPK8KDM4ENTRK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |