Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874645 | 1.00 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RAPPBCHE | |
| SCHEMBL6873084 | 0.92 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RAPPBCHE | |
| SCHEMBL6873090 | 0.92 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RAPPBCHE | |
| SCHEMBL6880955 | 0.90 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RAPPBCHE | |
| SCHEMBL6880961 | 0.90 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RAPPBCHE | |
| SCHEMBL6868105 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RAPPBCHE | |
| SCHEMBL6868098 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RAPPBCHE | |
| SCHEMBL6874094 | 0.89 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RCYP2D6USP2 | |
| SCHEMBL6874098 | 0.89 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RCYP2D6USP2 | |
| SCHEMBL6874814 | 0.88 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RAPPBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |